GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs1411478 | 1 | rs6425658 | chr1:180956985 | MR1 | chr1:181003139-181024633:+ | -0.13 | -3.45 | 0.000602 | Progressive supranuclear palsy |
| THCA | cis | rs1411478 | 1 | rs6425658 | chr1:180956985 | STX6 | chr1:180913175-180992046:- | -0.19 | -3.9 | 0.000108 | Progressive supranuclear palsy |
| THCA | cis | rs7116495 | 1 | rs642573 | chr11:71780854 | FAM86C | chr11:71498557-71512276:+ | 0.3 | 3.78 | 0.000176 | Severe influenza A (H1N1) infection |
| THCA | cis | rs7551345 | 1 | rs6425747 | chr1:31869978 | ZCCHC17 | chr1:31769842-31837780:+ | -0.29 | -5.28 | 1.92E-7 | Schizophrenia |
| THCA | cis | rs7523455 | 1 | rs6426622 | chr1:19331891 | TMCO4 | chr1:20008707-20126758:- | -0.16 | -3.64 | 0.000303 | Methotrexate phramacokinetics (acute lymphoblastic leukemia) |
| THCA | cis | rs4656958 | 1 | rs6427553 | chr1:160855813 | CD244 | chr1:160799951-160832645:- | -0.12 | -3.38 | 0.000782 | Crohn's disease;Ulcerative colitis;Inflammatory bowel disease |
| THCA | cis | rs4656958 | 1 | rs6427553 | chr1:160855813 | ITLN1 | chr1:160846332-160854960:- | 0.2 | 3.35 | 0.000868 | Crohn's disease;Ulcerative colitis;Inflammatory bowel disease |
| THCA | cis | rs2292096 | 1 | rs6427860 | chr1:200833995 | DDX59 | chr1:200610119-200639126:- | -0.22 | -3.42 | 0.000687 | Epilepsy |
| THCA | cis | rs642803 | 1 | rs642803 | chr11:65560620 | NAALADL1 | chr11:64812297-64826014:- | -0.12 | -3.39 | 0.00077 | Urate levels |
| THCA | cis | rs642803 | 1 | rs642803 | chr11:65560620 | SNX32 | chr11:65601410-65621170:+ | -0.21 | -3.72 | 0.000227 | Urate levels |
| THCA | cis | rs7551732 | 1 | rs6428476 | chr1:89126005 | CCBL2 | chr1:89401456-89458643:- | 0.64 | 14.16 | 2.88E-38 | Height |
| THCA | cis | rs6429082 | 1 | rs6429082 | chr1:235600129 | B3GALNT2 | chr1:235610533-235667781:- | 0.2 | 6.14 | 1.71E-9 | Adiposity |
| THCA | cis | rs6429082 | 1 | rs6429082 | chr1:235600129 | GPR137B | chr1:236305832-236372208:+ | 0.19 | 3.35 | 0.000865 | Adiposity |
| THCA | cis | rs6429082 | 1 | rs6429082 | chr1:235600129 | TBCE | chr1:235530728-235612280:+ | 0.13 | 3.87 | 0.000122 | Adiposity |
| THCA | cis | rs4660306 | 1 | rs6429567 | chr1:45956700 | AKR1A1 | chr1:46016498-46035720:+ | -0.14 | -3.78 | 0.000174 | Homocysteine levels |